Introduction for Tea extract EGCG
Tea extract Epigallocatechin-3-gallate is one of the main active ingredients of green tea, accounting for 50% to 60% of catechins. It has the functions of scavenging free radicals and reducing oxidative damage. It is not toxic to normal tissues and cells, but The prevention and treatment of cancer has a positive effect.
Cancer stem cells, CSCs, are a kind of special cells commonly found in cancer tissues. They are found in various cancer tissues such as breast cancer, liver cancer, lung cancer and glioma. They are migration invasive, self-renewing and strong. The characteristics of drug resistance, such as cancer, metastasis formation, anti-release (chemotherapy), cancer recurrence, etc., are directly related to cancer treatment.
Migrating cancer stem cells, MCSs are one of the important subgroups of CSCs, which can be detached from the primary tumor and transferred to the organs through the blood and lymphatic system, and colonized to form metastases in a suitable microenvironment. In the early stage of migration, MCSs overexpressed migration and invasive key factors to obtain motility, up-regulated Matrix metalloproteinases, MMPs expression levels, degradation of extracellular matrix, release of extracellular matrix binding to cells, and migration and invasion of cancer cells.
The inhibitory effect of Tea extract EGCG on MMPs has two pathways, one is to directly inhibit the expression level and activity level of MMPs, and the other is to enhance the expression of MMPs to inhibit the expression of molecules. The involved signaling pathways include AKT, ERK and NF-κB. In breast cancer cells, Tea extract EGCG down-regulates HGF expression, decreases Met phosphorylation and attenuates AKT and ERK signaling pathways, inhibits FAK and ERK binding to the MMP-9 promoter region, and down-regulates MMP-9 expression and activity levels. Inhibits cancer cell migration and invasion.
Self-renewal is one of the main characteristics of CSCs, which is directly related to the occurrence of cancer and metastasis. Abnormal activation of stem cell-associated signaling pathways such as Wnt/β-catenin, mTOR, and Hedgehog are the main reasons for the maintenance of self-renewal properties of CSCs. The development of drugs targeting these signaling pathways is the key to the treatment of CSCs. Some studies have found that Tea extract EGCG inhibits related signaling pathways. effect.
Tumor-producing is a key feature of CSCs and is directly related to the formation of primary tumors and metastases. The development of specific drugs for the tumorigenicity of CSCs is the key to targeted therapy of CSCs. Previous studies have found that Tea extract EGCG has an inhibitory effect on the tumorigenicity of breast cancer and prostate cancer cells.
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