Genistein is an important component of soybean isoflavones, also known as genistein and genistein.
"Mainly exists in the form of free aglycones and glycosides. Its chemical structure and molecular weight are similar to estradiol, which can compete with estrogen receptor, thereby interfering with the function of estrogen and playing a biological role. Its physiological functions are mainly reflected in the inhibition of enzyme and growth factor, blocking the activity of L-tyrosine kinase, inhibiting lipid peroxidation, clear free radicals in the body, regulating the cycle of cell activity, hindering the stroke of cardiovascular and cerebrovascular diseases, and preventing cancer and cancer treatment.
Genistein is usually a solid, more than 100 C melting point, stable at normal temperature, yellow white powder, easy to dissolve in alcohols, esters and ketones, insoluble in water, difficult to dissolve in petroleum ether, hexane and so on: polyphenols.
1. Prevent the occurrence of cancer.
Reactive oxygen species play an important role in carcinogenesis, especially in the process of promoting cancer. The role of Genistein in preventing cancer is related to its antioxidant properties. The phenolic hydroxyl group acts as an oxygen donor to react with the free radicals to form corresponding ions or molecules. Genistein containing phenol hydroxyl can reduce oxygen free radicals, reduce its damage to biological macromolecules, thereby reducing the incidence of tumors.
2 block the cancer of the cell.
The main link of Genistein to inhibit the transformation of malignant cells is in the stage of initiation and cancer promotion. Genistein antagonized the proliferation of TPA, the expression of ODC gene and other biological effects are the main mechanisms of the chemical prevention of cancer.
3 Genistein has inhibitory effect on tumor cell proliferation.
This effect is achieved by inducing apoptosis. Induction of apoptosis is a common pathway for anticancer drugs of various mechanisms. Drug induced apoptosis is one of the hot topics in cancer research. Genistein inhibited the proliferation of human gastric cancer cells in vitro, and increased the inhibitory effect with increasing doses.
4 Genistein can enhance the radiosensitivity of esophageal cancer cells and enhance the effect of radiotherapy.
The mechanism is related to blocking the survival signal transduction pathway. It is suggested that Genistein can be used as a therapeutic agent to improve the efficacy of radiotherapy.
5 inhibition of cell cycle
Genistein induces high P53 protein content in malignant cells by inhibiting the activity of topoisomerase II and tyrosine protein kinase, causing cell cycle arrest, inhibiting the proliferation of malignant cells and promoting the programmed cell death of malignant cells.
6. induced apoptosis
Inducing apoptosis is an important way to kill tumor cells by most anti-tumor drugs. Genistein regulates gene expression and induces cell apoptosis by inhibiting protein tyrosine kinase (PTK) and topoisomerase II activity. Genistein is an inhibitor of PTK and topoisomerase II, which blocks the conduction of the growth excited signal by inhibiting the phosphorylation of protein tyrosine and causes cell cycle arrest; by inhibiting the activity of topoisomerase II and blocking the reconnection of the broken DNA caused by the action of topoisomerase II in DNA replication, the intracellular DNA fragments are caused. It causes cell growth inhibition and death, and causes some genes related to DNA damage or cell cycle regulation, such as the increase of p53 gene expression, the decrease of bcl-2 gene expression, the cell cycle arrest in the G2 phase, and eventually the cell necrosis or apoptosis.
7. induced differentiation of malignant cells
Genistein has a variety of cell differentiation induction, which can reverse the cancer cells to normal cells or close to normal cells and affect oncogene expression in the early stage of cell action. The mechanism of Genistein induced differentiation is mainly by inhibiting the activity of protein tyrosine kinase (PTK), reducing the level of protein tyrosine phosphorylation, causing changes in the structure and function of cytoskeleton, thus affecting the morphology, secretory function and differentiation properties of cells, and changing the related genes (P53 eggs) by inhibiting the topoisomerase inhibition. The expression of C-myc protein can induce differentiation of cancer cells.
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