Introduction for Sea backthorn Extract
Isorhamnetin, a kind of Sea Buckthorn Extract, molecular formula C16H12O7, is pale yellow needle crystal. Isorhamnetin is present in a variety of plants and is particularly abundant in seabuckthorn. Sea Buckthorn Extract is one of the primary flavonoid aglycones contained in seabuckthorn. In recent years, there have been many reports on the hypoglycemic effect of seabuckthorn and seabuckthorn flavonoids. However, there are few reports on the hypoglycemic activity of isorhamnetin in seabuckthorn. With the high incidence of diabetes in recent years, many research institutions have Li Su conducted a more in-depth study.
Diabetes mellitus (DM) has become a public health problem that seriously endangers human health, and China is one of the countries with the fastest growing diabetes prevalence. Diabetes has been listed as one of the ten major diseases of the “New Drug Creation Technology Major Project”, and it is extremely urgent to research and develop new diabetes treatment drugs.
Alpha-glucosidase inhibitors are a new class of anti-diabetic drugs that can significantly reduce postprandial blood glucose levels in diabetic patients, thereby reducing the incidence of diabetic complications, and have been widely used in clinical treatment. Acarbose is a commonly used α-glucosidase inhibitor in clinical practice. By comparing the inhibitory activities of different concentrations of isorhamnetin on α-glucosidase, the results show that as the concentration of Sea Buckthorn Extract isorhamnetin increases, it is α- The inhibition rate of glucosidase increased in an S-shaped curve. After the concentration of isorhamnetin reached 0.5 mg/mL, the inhibition rate basically stabilized. Comparing the inhibitory effects of different concentrations of Sea Buckthorn Extract isorhamnetin and 1 mg/mL acarbose on α-glucosidase, it can be seen that 0.1 mg/mL isorhamnetin inhibits α-glucosidase with 1 mg/mL Aka The sugar is quite. It is proved that Sea Buckthorn Extract isorhamnetin has a certain role in inhibiting diabetes. With the deepening of research, it is believed that isorhamnetin and its derivatives will have better effects.
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