Introduction for Lutein for eye
Lutein for eye is an oxygenated carotenoid and one of the important nutrients in the human retina, mainly found in the macula and lens of the retina of the eye. Lutein cannot be synthesized by the human body, so it is mostly absorbed from food or breast milk and enters the lens and the macula of the retina to absorb the blue light harmful to the eyes and exert antioxidant effects. It is especially important for preventing and improving age-related macular degeneration and cataract diseases. However, Lutein for eye has poor water solubility and limited application. In order to increase the drug loading and improve the efficacy of the preparation, a laboratory has prepared lutein into albumin nanoparticles, and further loaded into an ion-sensitive gel material to form an eye drop.
An ophthalmic in situ gel, also known as an ophthalmic gel, refers to a semi-solid ophthalmic formulation that forms a non-chemically crosslinked phase immediately after administration in a solution state under physiological conditions. An ion-sensitive ophthalmic in situ gel is one of which is cross-linked mainly by complexing the gel matrix with ions in the tear fluid. Compared with ordinary gel preparations, it can increase the affinity with tissues, prolong the residence time and release time, reduce the number of administrations, and improve bioavailability. Because of its accurate dose, good patient compliance, high bioavailability, long residence time and good controlled release properties, it has become a hot spot in the field of ophthalmic preparation research.
Lutein for eye ionic in situ gel. Ion-sensitive in situ gels are based on the interaction of gel molecules with cations, ie, the phase transition of the formulation at the site of administration, from liquid to gel. Since the eye is rich in a lot of tears, and the cations such as Ca2+, Na+, K+ in the tears, the carrier gellane used in the in situ gel can complex with these cations in the tear fluid to form a gel in the eye, enabling it to adhere to The conjunctival sac and corneal surface are expected to significantly improve the short-term retention time of common eye drops, thereby reducing the number of administrations, delaying drug release, improving bioavailability, and having a good market effect.
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