Introduction for Isorhamnetin
Isorhamnetin is a known flavonoid with a structure of 3,5,7,4 ́-OH3 ́-CH3, which is widely found in the flowers, fruits and leaves of various plants such as ginkgo and sea buckthorn. Recent studies have found that isorhamnetin has endothelium protection, anti-atherosclerosis, anti-myocardial ischemia, blood pressure lowering, anti-oxidation and other cardio-cerebral vascular protective effects, and has the ability to inhibit adipocyte differentiation and anti-hypoxia, Anti-tumor, hypoglycemic, anti-inflammatory, anti-viral and other effects.
Isorhamnetin has a protective effect on endothelial cells damaged by H2O2. Isorhamnetin has a significant protective effect on endothelial cell apoptosis induced by oxidized low density lipoprotein, and its mechanism may be related to inhibition of oxidized low density lipoprotein damage caused by lectin-like oxidized low density lipoprotein receptor 1 and Up-regulation of Caspase-3 mRNA expression and decreased release of nitric oxide. Isorhamnetin acts on nuclear factor kappa B and STAT-1 to affect the activity of inducible nitric oxide synthase, and has an anti-inflammatory effect, thereby protecting the integrity of the vascular endothelium.
Isorhamnetin has a protective effect on myocardial ischemia-reperfusion injury, and has a certain concentration effect. Its protective mechanism is to reduce the damage of myocardial cells induced by ischemia-reperfusion by inhibiting the activity of lactate dehydrogenase. Death is also related to signaling pathways such as NF-κB.
Isorhamnetin has a blood pressure lowering effect. Studies have shown that the possible mechanism of vasopressin vasopressor is to reduce intracellular calcium ion concentration by dual inhibition of voltage-dependent calcium channels and manipulated calcium channels in vascular smooth muscle cells. Effects of isorhamnetin on vascular smooth muscle intracellular free calcium in spontaneously hypertensive rats showed that isorhamnetin had no effect on vascular smooth muscle intracellular calcium concentration at rest, but inhibited by potassium chloride, norepinephrine Increased intracellular calcium concentration in vascular smooth muscle cells.
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