Introduction for Isorhamnetin powder
Isorhamnetin powder, a kind of flavonoids, is mainly derived from the fruit of Hippophae fhamnoides L. It is an aglycone derived from the flavonoids of Ginkgo biloba and is also a direct metabolite of quercetin. . Flavonoids are a group of compounds rich in seeds, citrus fruits, vegetables, and the like. Many flavonoids have been used in the treatment of cancer, and the anti-tumor properties and efficacy of flavonoids have been recognized and studied by more and more people. Quercetin is a plant-derived bioflavonoid that exhibits anti-inflammatory, anti-oxidant, anti-cancer effects and other biological functions in vivo and in vitro. Recent research has found that the intermediate metabolite of quercetin, Isorhamnetin powder, exhibits a stronger anti-tumor effect in colon cancer cells compared to quercetin. The anti-tumor effect of isorhamnetin has been studied in many different types of cancer, including colorectal cancer, skin cancer, and gastric cancer. As far as we know, isorhamnetin has not been studied in lung cancer. Therefore, more and more studies are beginning to focus on the efficacy and related mechanisms of isorhamnetin in lung cancer.
Lung cancer is the leading cause of cancer-related death worldwide. Lung cancer is generally classified into small cell carcinoma and non-small cell carcinoma, of which non-small cell carcinoma accounts for about 85% of all lung cancer. Non-small cell lung cancer can be divided into squamous cell carcinoma, adenocarcinoma and large cell carcinoma. Squamous cell carcinoma is dominant, and anatomical parts can be divided into central lung cancer and peripheral lung cancer. So far, although lung cancer has a variety of treatments, including chemotherapy, radiation therapy, and surgical resection, non-small cell lung cancer has survived less than 20% in only 5 years. Therefore, it is very urgent to develop new and effective agents and methods for treating non-small cell lung cancer!
Early studies have shown that isorhamnetin powder has the efficacy of inhibiting inflammatory responses in a variety of different models, such as inflammatory bowel disease models and paw swelling models. The molecular mechanisms that can induce these models are: By inhibiting the different pathogenesis of NF-KB activation. It was also found that isorhamnet has a protective effect on LPS-induced acute lung injury through the signaling pathways of MAPK and NF-KB. With the development of the natural sciences, many studies have found that isorhamnetin has a good inhibitory effect on many different types of tumors. The anti-inflammatory and growth-suppressing properties of many cancers have been paid attention to, including skin, stomach cancer, etc., and even the role of isorhamnetin powder in the chemical protection of colon cancer, the specific molecular mechanism involved needs further Inquiry. At the same time, Isotrepine has down-regulated some key factors involved in the inflammatory response, such as COX2, PGE2, TNF-α and NF-κB.
Isorhamnetin powder also has preventive and therapeutic effects in cardiovascular disease. Isorhamnetin powder protects epithelial cells from hypoxia, lowers blood pressure and ischemia damage to ventricular myocytes, protects human keratinocytes from UV damage, and protects doxorubicin-induced cardiotoxicity in vivo and in vitro. H2O2-induced oxygen damage in H9c2 cardiomyocytes can also be prevented by isorhamnetin. In particular, the efficacy of isorhamnetin in tumors has received much attention, and it has been found that isorhamnetin powder is a natural and powerful anticancer drug in many tumor cell lines.
Carton: 1kg with double plastic container inside/Aluminum foil bag outside;
25kg with double plastic container inside/Fiber drum outside.
or as customer’s requirement.
Suitable for ≤50kgs
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Suitable for ≥50kgs
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Suitable for ≥500kgs
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