Indole-3-carbinol Melanoma

Indole-3-carbinol Melanoma

● Systemic lupus erythematosus
● Effect in recurrent respiratory papillomatosis
● Melanoma
● Indole-3-carbinol and cancer


What is Indole-3-Carbinol?

Pure indole-3-Carbinol is an off-white solid belonging to the group of indoles. Indole-3-carbinol is only formed in these vegetable after crushing or during cooking.


Indole-3-carbinol is made from indole-3-glucosinolate by the enzyme myrosinase. This enzyme is only activated after maceration of the vegetables.

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Investigation of mechanisms by which consumption of indole-3-carbinol might influence cancer incidence focuses on its ability to alter estrogen metabolism and other cellular effects.


Indole-3-carbinol induces a G1 growth arrest of human reproductive cancer cells. This is potentially relevant to the prevention and treatment of cancer, as the G1 phase of cell growth occurs early in the cell life cycle, and, for most cells, is the major period of cell cycle during its lifespan. The G1 phase is marked by synthesis of various enzymes that are required in the next ("S") phase, including those needed for DNA replication.


Indole-3-carbinol causes proliferation arrest and apoptosis in human melanoma cells. Kim YS et al showed that the master regulator of melanoma biology, Micropthalmia-associated transcription factor (MITF-M) was downregulated by Indole-3-carinol to induce apoptosis.

Systemic lupus erythematosus

Indole-3-carbinol can shift estrogen metabolism towards less estrogenic metabolites. Systemic lupus erythematosus (SLE, or lupus), an autoimmune disease, is associated with estrogen.


Women with lupus can manifest a metabolic response to indole-3-carbinol and might also benefit from its antiestrogenic effects.

Effect in recurrent respiratory papillomatosis

There is evidence suggesting that indole-3-carbinol may have an effect on human papillomavirus infected cells in both pediatrics and adult patients.

How Does Indole-3-Carbinol Help With Breast Cancer?

Recent studies have shown that I3C significantly prevents breast, cervical and endometrial cancer in women and prevents prostate cancer in men. Studies proved that I3C not only stopped 54-61% of human cancer cells from growing, but actually provoked the cells to self destruct. Indole-3-carbinol might be one of the most effective ways to reduce the risk of breast and other cancers. In addition, the I3C works synergistically with artemisinin and quercetin for maximal cancer protection.


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