Introduction for EGCG
Nearly 400 million people worldwide have diabetes, and in 2015 about 5 million people died of diabetes and its complications. At present, there are more than 100 million people with diabetes in China, and more than 200 million people may be suffering from this disease in the next 10 years. Diabetes will also become a major disease affecting the physical and mental health and quality of life of our people. Diabetes mellitus (DM) is a syndrome characterized by chronic hyperglycemia due to insufficient insulin secretion or defective effects, accompanied by disorders such as fat and protein metabolism disorders. At present, the etiology and pathogenesis of diabetes are not fully understood. Clinically, symptoms such as polyuria, polydipsia, polyphagia, and weight loss may occur. Severe cases are prone to diabetic nephropathy, nonalcoholic fatty liver disease, eye diseases, neuropathy and feet. Complications such as ulcers. Common diabetes is divided into type 1 and type 2.
Epigallocatechin gallate, EGCG powder, is an ester of gallic catechol with gallic acid and belongs to catechin. EGCG is the most abundant catechin in most green teas and has the highest EGCG content in all plants. A large number of studies have confirmed that EGCG powder can activate mitochondrial respiratory chain by inhibiting inflammatory factors and activating signaling pathways such as AMP-dependent/activated protein kinase (AMPK) and protein kinase B (Akt). It works to protect islet cells, alleviate insulin resistance, promote the accumulation of glycogen in cells, and play a certain therapeutic role in diabetes.
Animal studies have shown that EGCG powder can improve the insulin sensitivity and glucose tolerance of the test body, lower blood sugar and insulin resistance, and have certain therapeutic effects on diabetes. Studies have shown that continuous injection of EGCG powder into SD rats revealed that endocrine factors such as insulin, glucose, triglycerides and cholesterol levels were reduced. In epidemiological studies, the effects of green tea EGCG powder on insulin resistance and dyslipidemia in patients with type 2 diabetes were evaluated. After 16 weeks of the trial, the insulin resistance index and triglyceride levels in the blood of the EGCG group decreased significantly. High-density lipoprotein cholesterol increased significantly; in a study of healthy volunteers, blood glucose and blood insulin levels were decreased after taking green tea extract with EGCG powder for 12 weeks, and EGCG powder was found to be inhibited. High glucose-induced vascular inflammation in human umbilical vein endothelial cells; these studies suggest that EGCG powder has a mitigating effect on diabetes-related complications.
EGCG powder has the potential to be developed as a drug or adjunctive drug for the treatment of diabetes. In particular, EGCG powder protects DNA and alleviates oxidative damage. It is a common entry point for the treatment of diabetes and cancer, and has important medical research value. Although the oral bioavailability of EGCG powder is so low that a few epidemiological studies have questioned the efficacy of EGCG in anti-diabetes, with the development of pharmaceutical technology and EGCG-derived technology, this problem will eventually be solved scientifically. As the highest content of catechins in tea, EGCG has developed a broad prospect for the prevention and treatment of metabolic syndrome drugs such as diabetes.
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