Centella asiatica Glycoside is the main monomer extracted from Centella asiatica. It has been found that Centella asiatica Glycoside can inhibit the proliferation of fibroblasts. Centella asiatica Glycoside can inhibit the proliferation of fibroblasts.
Reducing the expression of TGF-beta 1 in promoting scar hyperplasia and increasing the expression of TGF-beta 3 in inhibiting scar hyperplasia resulted in a significant decrease in the expression of matrix protease inhibitor (TIMPS) and an increase in the relative proportion of MMPS/TIMPS to promote the degradation of type I collagen and alleviate scar hyperplasia. Other studies have found that asiaticoside inhibits scar hyperplasia by increasing Smad7 expression of R-Smads transduction signal, inhibiting the pathological effect of TGF-beta and inhibiting the proliferation of fibroblasts. Furthermore, asiaticoside can significantly affect the ultrastructure of fibroblasts and has a direct effect on the structure of rough endoplasmic reticulum, thus inhibiting the synthesis of collagen, preventing scar formation and development in a dose-dependent manner; asiaticoside can effectively promote the expression of CyclinB1 and PCNA, and advance the S and G2 phases of cell cycle, thus accelerating cell proliferation and promoting wound healing. Furthermore, in vitro studies have shown that asiaticoside can interfere with the DNA synthesis of fibroblasts, thereby inhibiting scar proliferation.
Centella asiatica preparation can also improve anxiety symptoms. Another study showed that emotional disorders were closely related to stress-induced neuroendocrine dysfunction. Abnormal hypothalamus-pituitary-thyroid axis was associated with primary mental disorders, and depressive patients had abnormal ACTH and corticosteroid secretion.
In the rat model of depression induced by long-term unpredictable stress stimulation, asiaticoside can improve the disordered hypothalamic-pituitary-adrenal cortex and hypothalamic-pituitary-thyroid axis in depressed rats, increase the body's resistance to various non-specific stimuli, and avoid the regulation of hypothalamic-pituitary-adrenal cortex and hypothalamic-pituitary-thyroid axis caused by excessive stress. Functional disorders play an antidepressant role
Asiaticoside has obvious inhibitory effect on burn scar
Gotu Kala Extract
Can, Drum, Glass Container, Plastic Container
Shaanxi, China (Mainland)
20 Ton/Tons per Month
Packaging & Delivery
TECA Powder Bulk & Private Label Packaging for your options:
* 1~5 kg in a Al-Foil Bag w/ Zip lock Bag inside
* 5~20 kg in a Paper Carton
* 25kg in a Paper Drum w/ Double Plastic Bags inside
3 days after payment
Shaanxi Huatai Bio-fine Chemical Co., Ltd is a professional manufacturer and supplier of natural plant extracts. Her owner has been specialized in this field since 1990s.