The skin is a very important defense system of the human body. It is a natural barrier that separates the human body from the outside world. It also has the function of the reaction system of metabolism and biochemical immunity. In the epidermis, the skin's immune system including cytoplasm and control immunity Langerhans cells (Langer-hansCells) and keratinocyte. The Langerhans cells in recent years has been confirmed to have very special relationship between it and the skin macrophages in two, plays a very important role in skin immune. Under the cuticle of skin, there are many immune networks composed of Langerhans cells. Langerhans cells are dendritic cells, whose antennae reach the stratum corneum cells, and are the receptors of beta glucan. Because -1,3-D-- beta glucan is a planar spiral structure, combining it with the cell membrane receptor, causing a series of solid chemical changes, resulting in the activation of macrophages, produce a variety of cytokines, epidermal growth factor (EGF), tumor necrosis factor (TNF-) and vascular endothelial growth factor (AF). On aging or wrinkled skin, the increase of epidermal growth factor can increase the production of collagen and elastin, and improve the appearance of skin, and make fine wrinkles disappear.