There are 3 main methods for the preparation of coenzyme Q10: extraction and separation, chemical synthesis and biosynthesis. The comparison of the three methods is as follows：
Advantages and disadvantages
The oil of the liver, myocardium, and plant seeds or tender shoots or leaves
The cost of production is high and the raw material is not easy to get.
Total chemical synthesis
Advantages: the raw materials are cheap and easy to be obtained, and the regional selectivity and stereoselectivity of the products are high. Shortcomings: the construction of side chain needs multiple coupling, the total yield is low, and it is difficult to realize industrialization.
Semi chemical synthesis
Using natural solanesol as the key raw material
The price of pure solanesol is very expensive, many synthetic steps, more by-products, difficult separation of chiral substances and so on.
Plant cell culture
It is in the preliminary study stage and has not yet entered the pilot and industrial production.
Microbial cell fermentation
Photosynthetic bacteria, Agrobacterium tumefaciens, Pseudomonas sp., fission yeast
The raw material is cheap and rich, the separation process of the product is relatively simple, and there is no chiral problem.
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