As the worlds of beauty and cutting-edge science become increasingly intertwined by the minute, the role that our genes play in healthy, youthful skin has never been clearer, with findings once reserved for cancer research and autoimmune diseases now offering the clues about the ageing face.
Because 90 per cent of the chemical energy cells use to survive is created by mitochondria, mitochondrial dysfunction is inherently linked with ageing in humans. When scientists activated a mutation in mice that caused their mitochondrial function to decline, they started losing hair, showing gray hair, and developing wrinkles (the product of both intrinsic and extrinsic ageing) within a span of four to eight weeks. " says Keshav Singh, one of the lead researchers. "It suggests that epigenetic mechanisms underlying mitochondria-to-nucleus cross-talk must play an important role in the restoration of normal skin and hair phenotype."
As the study, published in Cell Death & Disease, notes, humans are still a ways off from accessing this cutting-edge science. But considering that advanced epigenetic technology has already begun trickling down into the skincare market, these most recent findings may well be a strong harbinger of what's to come in the pursuit of eternal youth.
Ferulic acid can inhibit or reduce the proliferation activity of melanocytes. The number of melanocytes from 0.1 to 0.5% ferulic acid can be reduced from 117 + 23/mm2 to 39 + 7/ mm2. At the same time, ferulic acid can also inhibit tyrosinase activity and the concentration of ferulic acid in 5mmol/L. The inhibition rate of tyrosinase activity is up to 86%. Even if the concentration of ferulic acid was only 0.5mmol/L, the inhibition rate of tyrosinase activity could reach about 35%.
Ferulic acid has a strong antioxidant activity, and has a strong clear effect on hydrogen peroxide, superoxide radical, hydroxyl radical and peroxynitrite. Ferulic acid can not only scavenge free radicals, but also regulate physiological functions of human body, producing free radical enzymes and promoting the production of scavenging free radicals.
It is reported that ferulic acid has the ability of sunscreen. Ferulic acid can effectively absorb ultraviolet light from 290 to 330nm wavelength range to prevent or reduce the damage of ultraviolet light on the skin.
Ferulic acid is an antioxidant which neutralizes free radicals (superoxide, nitric oxide and hydroxyl radical) which could cause oxidative damage of cell membranes and DNA. Ferulic acid helps to prevent damage to our cells caused by ultraviolet light. Exposure to ultraviolet light actually increases the antioxidant potency of ferulic acid. Ferulic acid is often added as ingredient of anti-aging supplements. Studies have shown that ferulic acid can decrease blood glucose levels and can be of help to diabetes patients.
When applied topically, ferulic acid acts like other antioxidants in that it helps to slow the ageing process by reducing the effects of damaging free radicals on the skin. It is also thought to protect against sun damage, as well as assisting in skin's regeneration functions to tackle skin that has already been over-exposed. In addition it has the benefit of working well alongside other antioxidants, enhancing the stability and the efficacy of vitamins C and E.
Ferulic acid seems to protect against cancer, bone degeneration, menopausal symptoms (hot flushes). Like many other antioxidants, ferulic acid reduces the level of cholesterol and triglyceride, thereby reducing the risk of hearth disease. Ferulic acid seems to reduce the risk of many cancers, including cancer of the stomach, colon, breast, prostate, liver, lung and tongue.
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