Melanin is a kind of deep pigments. It can cause skin coloring. It is generated by a series of biochemical reactions, such as phenylalanine or tyrosine oxidation, in melanocytes. Tyrosinase has tyrosine hydroxylase activity (catalyzing tyrosine to DOPA) and dopa oxidase activity (catalyzing DOPA to DOPA), which is the key factor to synthesize melanin by melanocytes.
Arbutin can rapidly penetrate the skin, not affect cell proliferation in the concentration at the same time, can effectively inhibit the activity of tyrosinase in the skin, blocking the formation of melanin. It directly combines with tyrosinase to compete with DOPA binding sites, accelerate the decomposition and excretion of melanin, and reduce the skin pigment deposition.
In fact, the main effect of arbutin is brightening effect (skin lightening) can make the skin look beautiful. Europe and the United States the use of arbutin is the use of this function. At present, with the increasing use of patent expires, the past only in high-end cosmetics was the use of arbutin has become more and more popular.
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