Introduction for Neohesperidin dihydrochalcone
Citrus is a very common fruit tree cultivated in the south of China. In recent years, the planting area has been expanding and the output has risen sharply. The fruit peel accounts for about 20% of its fruit quality. If it is comprehensively utilized, it will undoubtedly have significant social and economic significance. The discovery of Herowitz has not only opened up a new path for the comprehensive utilization of Neohesperidin dihydrochalcone, but also brought good news to obese patients and diabetics.
Neohesperidin dihydrochalcone is quite sweet and soluble and stable in water, so it can be used as a food additive of various types. It also has great pharmacological effects, especially for obese patients and diabetic patients. The production process is mainly completed by the following two parts:
1 the conversion of flavanone glucoside to the corresponding intermediate chalcone, this step is carried out in lye;
2 The chalcone intermediate is hydrotreated to Neohesperidin dihydrochalcone in the presence of a hydrogenation catalyst.
The flavanone glucoside is mixed with a base, hydrogen gas is introduced (at room temperature and normal pressure), a hydrogenation catalyst such as palladium or platinum is added, and the mixture is stirred. After the completion of the reaction, dihydrochalcone is separated. The separation and purification of dihydrochalcone may be carried out by passing a catalyst-free dilute alkali solution into a column containing a cation exchange resin such as Amberlite 200 or a cation exchanger directly added to the alkali solution, followed by removal of the alkali solution, followed by Very pure Neohesperidin dihydrochalcone can be obtained from an alkali-free solution.
Contacting the flavanone glucoside with a relatively concentrated aqueous base solution, for example, contacting 20% to 25% of NaOH or KOH aqueous solution at room temperature to open the heterocyclic ring between the 1,2 positions to form the flavanone glucoside The ketone is recovered by conventional methods, and the system is acidified to precipitate chalcone. The chalcone obtained by acidification and precipitation is then contacted with hydrogen in the presence of a hydrogenation catalyst such as platinum, palladium or framework nickel to be hydrogenated to form Neohesperidin dihydrochalcone.
Due to the high price of the synthetic flavanone glucoside, its use value in production is limited. For this reason, it is necessary to find an inexpensive flavanone glucoside material. Naringin is a natural, inexpensive flavanone glucoside that can be extracted from the citrus peel, especially the peel of grapefruit. As mentioned above, the content of naringin in the citrus peel is very large, and the citrus peel accounts for about 20% of the fruit quality. China is also a big country producing citrus, especially the citrus resources in the south of the Yangtze River. Therefore, the synthesis of Neohesperidin dihydrochalcone using naringin has now become the mainstream method.
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