Neohesperidin Dihydrochalcone NHDC

Neohesperidin Dihydrochalcone NHDC

● the most striking new sweeteners
● a flavonoid derivative obtained
● extracted from natural citrus plants


Introduction for Neohesperidin dihydrochalcone NHDC

Neosporin dihydrochalcone NHDC is one of the most striking new sweeteners this year. It is a flavonoid derivative obtained by hydrogenating the new quercetin extracted from natural citrus plants. Because it has an excellent effect of shielding bitterness, it has been used as an additive by world-class feed production enterprises. In 1997, the Ministry of Health of China listed it as a supplement to the “Standards for the Use of Food Additives”. However, the original drug uses organic solvents such as acetone, ethyl acetate, methanol and ethanol in the production process. For many manufacturers who have requirements for solvent residues, detecting solvent residues is an important issue.

Detection of solvent residues

Column: HP - Innowax Elastic Quartz Capillary Column (30 m × 0. 32 mm, 0. 5 μm); Detector: FID; Column Temperature: Initial temperature 40 °C, held for 5 min, heated to 2 °C /min to 50 °C, then increase to 10 °C /min to 150 °C for 5 min; inlet temperature: 230 °C; detector temperature: 250 °C; nitrogen flow rate: 1. 5 mL /min; Split ratio: 1 : 1; Headspace conditions: Equilibrium temperature 80 °C, equilibration time 30 min, loop temperature 95 °C, transmission line temperature 105 °C, vibration 10 min, injection volume 1. 0 mL. The chromatograms of the control and the test solution are shown in Figure 1. The retention times of acetone, ethyl acetate, methanol and ethanol are about 5. 16, 6. 96, 7. 15, 8. At 53 min, the chromatographic peaks of each organic solvent were well separated.

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The solubility of Neohesperidin dihydrochalcone NHDC original drug in distilled water at room temperature is 8. 1 × 10 - 4 mol / L (0.5 g / L), but rises to 653 g / L at 80 °C, and the water does not interfere with the determination of residual solvent, so from the point of view of convenience, economy, safety and environmental protection Still choose water as a solution Agent. Among the four organic solvents measured, methanol and ethanol are polar substances, and the polar column is selected to better solve the tailing problem and improve the peak shape. When the initial temperature is 50 °C or above, the peak of the component to be tested is rapid, but it cannot be separated well. After repeated tests, the initial temperature is determined to be 40 °C, and the temperature is programmed to separate the peaks well.


Carton: 1kg with double plastic container inside/Aluminum foil bag outside; 

25kg with double plastic container inside/Fiber drum outside.

or as customer’s requirement.

Drum: 10kg,15kg,25kg




Shipping Terms

By express

By Air

By Sea

Suitable for ≤50kgs


High cost

Door to Door

Easy Pick Up Goods

Suitable for ≥50kgs


High Cost

Airport to Airport

Pick Up Goods by Customer

Suitable for ≥500kgs


Low Cost

Port to Port

Pick Up Goods by Customer

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Payment Terms

Western Union

Money Gram


Bank Transfer

Finishing workshop

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