Introduction for Curcumin
The first was the separation of a low molecular weight polyphenolic compound from Curcuma longa L. in 1870. In 1910, the chemical structure of bis-feruloylmethane was elucidated, followed by studies on its physiological and pharmacological effects. Significant progress has been made. With the deepening of research on curcumin, it has been found to have a wide range of pharmacological activities such as anti-inflammatory, anti-oxidation, lipid-lowering, anti-viral, anti-infective, anti-tumor, anti-coagulation, anti-fibrosis, anti-atherosclerosis and the like. , and low toxicity and small adverse reactions are gradually recognized.
The use of curcumin in the oriental medical system has a long history, and currently Western medicine is paying more and more attention to curcumin, which is currently one of the world's largest selling natural food colorants, the World Health Organization and the US food. The Food and Drug Administration and food additives approved for use in many countries. It is not only curcumin that attracts researchers as a non-steroidal anti-inflammatory drug, but because of its chemopreventive properties, curcumin has broad preventive properties for the disease. In view of the fact that modern medical research has found that many diseases in human body are related to the formation of free radicals and inflammatory reactions, the antioxidant activity and anti-inflammatory effects of curcumin have attracted widespread attention from scholars at home and abroad.
Free radicals are a class of highly oxidatively active groups produced during the metabolism of organisms. Antioxidant mechanism of curcumin: The yellow spice curcumin in Indian food has long been used as an effective drug for the treatment of infectious diseases. The effective prevention or corresponding therapeutic potential of curcumin for certain diseases is also thought to be related to its antioxidant effects.
Curcumin can directly scavenge free radicals (ROS and RNS), such as superoxide O2, H2 O2 and NO, in vitro and in vivo. Compared with other polyphenolic compounds (resveratrol and quercetin), curcumin was found to be faster in scavenging ROS. Curcumin reduces ROS production because it increases intracellular reduced glutathione levels and is associated with transcription factors (Nrf2).
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