Introduction for Curcumin
Curcuma longa L. is Zingiberaceae, Curcuma's plant, which is mainly produced in Asian countries such as India and China. According to Li Shizhen's "Compendium of Materia Medica" in the Ming Dynasty, the Tang dynasty pharmacy monograph "Tang Bencao" has a record of turmeric medicine. According to the "Chinese Pharmacopoeia" records: turmeric roots, bitter, warm, spleen, liver. It has the function of breaking blood and relieving pain. It is used for thoracic rib tingling, chest pain, heart pain, amenorrhea, phlegm, rheumatism, shoulder and arm pain, and swelling and pain.
Obesity is a metabolic abnormality that easily causes chronic diseases such as type 2 diabetes, hypertension, cardiovascular disease and cancer. Curcumin has a certain effect on these chronic diseases. It can inhibit the activation of peroxisomes by inhibiting NF-кB, STAT-3, Wnt/b-catenin, and increase the signal pathway of bioactive receptors PPAR-c and Nrf2 cells. Inflammatory response to cytokines, resistin, leptin, up-regulated related proteins such as adiponectin, inhibition of insulin resistance caused by obesity and obesity-related diseases, polysaccharides and inflammation, and reduced intake of high-fat (22%) diet Rat body weight, cholesterol content, adipose tissue microvessel density, vascular endothelial growth factor and its receptor expression, PPARγ and CCAAT/enhancer binding protein expression, inhibit adipose tissue vascular regeneration, regulate fat cell lipid metabolism.
Curcumin is currently one of the world's largest-selling natural food colorings with significant anti-inflammatory and anti-oxidant effects. Its antioxidant activity differs from its structurally functional groups, including methoxy, phenoxy and C=C double bonds. However, there are also some opinions that curcumin may not be a complete antioxidant under oxidative stress, but an oxidant. For decades, curcumin has played an important role in the treatment of inflammation-mediated diseases such as tumors, atherosclerosis, diabetes, rheumatoid arthritis, etc. It has shown that anti-inflammatory effects have always been the focus of scholars. . The anti-inflammatory effects of curcumin may be due to inhibition of COX-2, LOX, iNOS cytokine products (such as INF-γ, TNF) and other transcription factors (such as NF-κB). It has recently been discovered that curcumin can regulate the activity of corticosteroids in inflammatory reactions and become a new target for its anti-inflammatory effects.
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