Introduction for Neohesperidin dihydrochalcone skin
Chloasma is the most common acquired pigmented skin disease in facial pigmented plaques. It is usually distributed in the cheeks with a symmetrical butterfly shape. The light is light yellow or light brown, and the patch is scattered with the lower part of the eye. The person is dark brown or light black scattered on the face. Chlamyma patients are mostly young and middle-aged women. The research findings are mainly related to higher levels of estrogen and pregnancy, and the depth of stains is related to the intensity of ultraviolet radiation (sun exposure), season, endocrine and even the living habits of patients. There is also a certain relationship. The disease may have an adverse effect on the patient's appearance and may cause greater psychological stress on the patient.
Neohesperidin dihydrochalcone skin is a flavonoid derivative obtained by hydrogenating new hesperidin extracted from natural citrus plants. NHDC has been used as a food sweetener in the food industry for many years. Previous studies have shown that flavonoids mostly have the effect of scavenging free radicals in the skin, promoting skin metabolism, reducing pigmentation, moisturizing the skin, etc. As a flavonoid derivative, Neohesperidin dihydrochalcone skin has potential applications in antioxidant and antagonistic tyrosinase activities. value. Therefore, this study attempted to make Neohesperidin dihydrochalcone skin a topical gel for skin evaluation of melasma.
Thirty normal volunteers were tested with 2% Neohesperidin dihydrochalcone skin, 13 were cured, 14 were treated effectively, 16 were effective, 5 were ineffective, and the cure rate was 27.1%; the total effective rate was 89.6%; Of the 32 patients, 6 were cured, 8 were treated effectively, 12 were effective, 11 were ineffective, and the total effective rate was 81.3%. It has been proved to be safe by human patch test.
By inhibiting the tyrosinase activity of the new whitening agent Neohesperidin dihydrochalcone skin, it was confirmed that NHDC has a significant effect on the inhibition of tyrosinase activity, and the application safety of the preparation was confirmed by a human patch test. The commonly used food additive raw materials are expanded into a dosage form which can be used for the treatment of chloasma. It is found by the treatment of clinical chloasma in the control group that the gel has a certain effect on the treatment of chloasma.
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