Introduction for Licorice Flavonoids
Glycyrrhiza uralensis is the root and rhizome of the genus Glycyrrhiza. The active constituents are mainly glycyrrhizic acid, glycyrrhetinic acid, licorice flavonoids and licorice polysaccharide. Among them, licorice flavonoids have anti-oxidation, anti-arrhythmia, whitening, hypoglycemic and so on. Biologically active, widely used in food, pharmaceutical and beauty industries.
Licorice Flavonoids are a class of compounds that are widely found in nature and have a 2-phenylchromanthone structure. Studies have shown that licorice flavonoids play a role in inhibiting tyrosinase activity mainly by chalcone flavonoids, such as isoglycyrrhizin-glucoside apigenin, isoliquiritin and licorice chalcone, their special chemical structure is beneficial to The enzyme active center combines to exert an inhibitory enzyme activity.
Tyrosinase, also known as polyphenol oxidase, catechol oxidase, etc., is widely found in humans, animals, plants and microorganisms, and is an essential enzyme in melanin biosynthesis. Therefore, inhibition of tyrosinase activity can improve the tyrosinase metabolism of pigment cells in the skin, prevent the formation of pigmentation, and prevent the formation and whitening of freckles, chloasma, senile plaques and the like.
The plant used licorice flavonoids as raw materials, and used L-tyrosine and dihydroxyphenylalanine as substrates to determine the tyrosinase monophenols in glycerol buffer system at 37 ° C and pH=6.8. The inhibitory activity of enzyme and diphenolase activity, and the inhibition of tyrosinase by licorice flavonoids was confirmed from an experimental point of view.
The results showed that licorice flavonoids could effectively inhibit the activity of tyrosinase monophenolase and diphenolase. In the experimental concentration range, the inhibition rate of licorice flavonoids was 81.26% and 76.52%, respectively, and their IC50 values were 0.524. 1.254 mg·mL-1, which proved that licorice flavone has strong inhibitory effect on tyrosinase monophenolase and diphenolase, and the inhibition of monophenolase is stronger than that of diphenolase. Glycyrrhizin can effectively prevent The oxidation of L-tyrosine and L-dopa effectively reduces the production of melanin and prevents the disease and whitening caused by pigmentation.
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