Apple Leaves Extract Phloretin for Whitening Agents Lighten Spot 60-82-2

Apple Leaves Extract Phloretin for Whitening Agents Lighten Spot 60-82-2

● Phloretin is better than arbutin and kojic acid on inhibiting tyrosinase
● Anti-free radicals
● Dark spots removing
● Oil control
● Pink and Off-white can be choose

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Details

Apple Leaves Extract Phloretin for Whitening Agents Lighten Spot


Product introduction

Phloretin is a dihydrochalcone compound, is a new natural skin whitening agent, mainly distributed in apples and other juicy fruit peel and root bark. Phloretin has a weak estrogen activity.


Product parameter

logo.jpg Phloretin

Trade Name: Shaanxi Huatai Bio-fine Chemical Co., Ltd.

Common Name: Phloretin

Chemical Name : 2',4',6'-TRIHYDROXY-3-(4-HYDROXYPHENYL)PROPIOPHENONE

CAS No.: 60-82-2

EINECS No.: 200-488-7

Molecular Formula: C15H14O5

Molecular Structure:                phloretin1.jpg

Characteristics: White powder

Solubility: Dissolved in ethanol, 1,3-butanediol. Do not dissolved in water

Specification: Cosmetic grade

Category: Skin Care

Features: The Studies have shown that phloretin can inhibiting melanocytes, inhibiting tyrosinase activity, and has effects on various skin pigmentation. Phloretin also has Anti-inflammatory and immunosuppressive effects. Research showed that cause the phloretin, NO release volume of macrophage was significantly decreased under the stimulation of lipopolysaccharide (LPS) and IFN-γ.

Typical Dosage: 3‰-5‰

Packing: 1kg aluminum foil bag

Transport: Non-hazardous cargo(IMO/IATA)

Remarks: Safety and efficacy report available upon request.


Product feature application

Skin whitening. Kitayama Takashi [P] 93,213,729 Studies have shown that phloretin can inhibiting melanocytes, inhibiting tyrosinase activity, and has effects on various skin pigmentation. Compared with the natural ingredients arbutin and kojic acid, with the same concentration, phloretin is better than them on inhibiting tyrosinase, when it compounded with arbutin or kojic acid, can greatly improve tyrosinase inhibition ratio, about 100%.

Anti-inflammatory and immunosuppressive effects. Research showed that cause the phloretin, NO release volume of macrophage was significantly decreased under the stimulation of lipopolysaccharide (LPS) and IFN-γ. Phloretin has a potential anti-inflammatory effect. In immunosuppression, studies have shown that phloretin has a significant inhibitory effect on mouse T lymphocyte activation.

Phloretin induced cytotoxicity on lymphocytes N=6, *±S.control

Group

Dose/μmol·L-1

A

Survival rate/%

Negative




Control


0.140±0.002

/

Positive




Control


0.365±0.007

100

Phloretin

40

0.332±0.013

88.87


60

0.316±0.021

81.48


80

0.297±0.015

72.68

phloretin2.jpg

Figure :Proliferation of lymphocytes analyzed by CFSE-labelling (n = 4, x ± s).


Product qualification

phloretin.png

Deliver, shipping and serving

Applications: Widely used in cosmetic product as cream, paste, water solution and emulsion.


Packing:

1. 1kg with double plastic container inside/Aluminum foil bag outside.
2. 25kg with double plastic container inside/Fiber drum outside.
3. The final decision will be made by your company.

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