Introduction for Portulaca oleracea
Osteoporosis: In the past, it was considered to be a property of nutrition, metabolism, and endocrine diseases. With the deepening of bone immunology research, it is currently considered to be a chronic low-grade inflammatory disease. Due to various reasons, both primary and secondary osteoporosis are associated with immune dysfunction, and the resulting inflammatory response leads to an increase in osteoclast differentiation and formation, and the ability of mature osteoclasts to absorb is broken. Bone resorption and bone formation are in a steady state of bone remodeling, leading to excessive absorption and destruction of bone, causing bone diseases, which eventually develop into osteoporosis due to the reduction of bone mass at the beginning, thus achieving anti-inflammatory effects through anti-inflammatory effects. The study of osteoporosis has become a new hot spot.
Lipopolysaccharide, also known as endotoxin, is a major component of the cell wall of Gram-negative bacteria and binds to macrophage and monocyte surface receptors, resulting in activation of intracellular signaling molecules p38, JNK and nuclear factor kappa B pathways, Factors such as prostaglandin E2 (PGE2), interleukin 1, nuclear factor kappa B receptor activating factor ligand (RANKL) and tumor necrosis factor promote osteoclast differentiation and survival. Therefore, lipopolysaccharide is an important intermediary molecule that causes pathological bone destruction caused by inflammation.
The animal experiment of the anti-osteoporosis effect of the purslane was carried out by intraperitoneal injection of lipopolysaccharide to induce a mouse model of osteoporosis. The mouse femoral condyle bone structure was analyzed by computerized micro-tomography and pathological tissue section. The results of computerized tomography showed that the decrease of femoral bone volume fraction, trabecular bone number and trabecular bone spacing in the ethanol extract group of Portulaca oleracea were significantly inhibited, and the bone microstructure was effectively protected. Pathological tissue sections also showed that the femoral bone structure of the distal femur of the drug group was not significantly damaged. The above results indicate that purslane may be a new natural drug for the prevention and treatment of osteoporosis.
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