Introduction for Glabridin antifungal
Glabridin antifungal is one of the main components of traditional Chinese medicine licorice. It is a safe and non-toxic active active ingredient extracted from the medicinal plant licorice root and stem. It has anti-inflammatory, anti-allergic, anti-viral and immune regulation. And so on, to achieve the exact effect of clinical treatment of various diseases. In this study, we observed the formation of Listeria monocytogenes biofilm by different concentrations of glabridin antifungal. to investigate the antibacterial activity of G. glabra L. against L. monocytogenes biofilm.
Listeria monocytogenes is a food-borne pathogen of human and animal diseases. It is mainly used as food and is widely used in nature and various foods. It can still grow and reproduce in 4 °C environment, which can cause people, The incidence of livestock infection is high and the mortality rate is high. It can cause listeriosis after eating food contaminated with Listeria monocytogenes. Serious infection with Listeria can cause blood and brain tissue infection. In recent years, listeriosis has occurred worldwide, and the incidence of disease has risen, attracting widespread attention at home and abroad. Therefore, Listeria monocytogenes not only has an important impact on the development of animal husbandry, but also poses a hazard to people's health.
Glabridin antifungal has an inhibitory effect on the biofilm formation of Listeria monocytogenes. As the concentration of Glabridin antifungal increased, the experimental data decreased significantly, indicating that the increased concentration of glabridin antifungal uralensis increased the inhibition of L. monocytogenes biofilm formation. At the same time, at a certain concentration, with the extension of time, the inhibition of the formation of Listeria monocytogenes was also enhanced. Glabridin antifungal has a certain effect on the activity of tyrosinase. Therefore, it is possible that during the metabolic phase of the bacteria, the activity of one or a certain of the enzymes is disturbed, causing the growth of the bacteria to be hindered, and thus the formation of the biofilm is affected. It is also possible that the structure is destroyed. This prevents the bacteria from completing a specific physiological process and therefore cannot complete the construction of a normal biofilm. In addition, licorice has a killing effect on a variety of Gram-positive and negative bacteria.
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