Rhodiola mainly contains phenylpropanoids and flavonoids. Its unique active chemical constituents are phenylpropanoid esters, rosavin (the most active), rosin, rosarin, rhodiolin, salidroside and its aglycone, that is, Tyrol alcohol. Only Rhodiola rosea contains rosavin, rosin and rosarin.
Salidroside (Rhodioloside) is a glucoside of tyrosol found in the plant Rhodiola rosea. It is thought to be one of the compounds responsible for the antidepressant and anxiolytic actions of this plant, along with rosavin. Salidroside may be more active than rosavin, even though many commercially marketed Rhodiola rosea extracts are standardised for rosavin content rather than salidroside.
Salidroside [2-(4-hydroxyphenyl)ethyl β-D-glucopyranoside (SAS)] has been identified as the most potent ingredient of the plant Rhodiola rosea L. Previous studies have demonstrated that it possesses a number of pharmacological properties, including anti-aging, anti-fatigue, antioxidant, anticancer and anti-inflammatory properties.
Formal Name: 2-(4-hydroxyphenyl)ethyl-β-D-glucopyranoside
CAS Number: 10338-51-9
Molecular Formula: C14H20O7
Formula Weight: 300.3
Formulation: A crystalline solid
1. Promotes Nerve Health
Recent studies have isolated salidroside from Rhodiola rosea to determine its effects on the nervous system. Much of this research has determined that this bioactive compound positively supports the nervous system. Salidroside extract seems to protect nerves, promote nerve repair, regulate neurotransmitter release in the nervous system, and may prevent premature cell death. Findings also suggest that salidroside has great potential as a therapy against degenerative nervous system conditions.
2. Protects Against Brain Cell Damage
Salidroside may protect brain cells against degradation. One study found that Rhodiola and salidroside protected neurons from the damaging effects of toxins and stabilized cell function.
3. Supports Skeletal Health
It appears that the protective effects of salidroside extend to bone cell rejuvenation and development. Based on its success as an adaptogen and its ability to protect cells from oxidative damage, researchers tested a salidroside extract on bone formation and maturation. When used as an isolate, salidroside reduced bone loss. Once again, it protected against oxidative damage and slowed premature cell loss.
4. Stress Reduction and Weight Loss
Perhaps the most researched applications for Rhodiola rosea and salidroside is as a stress reducer which has also been linked to weight loss.
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