Apigenin is a phyto-chemical compound that is commonly recognized as a bioactive flavonoid (or flavones) and possesses all the essential characteristics and natural goodness of the flavonoid group. Its antioxidant, anti-inflammatory, and anti-stress properties have been scientifically proven.
It occurs naturally in a variety of fruits, vegetables, spices and herbs and is abundantly found in chamomile, which is the prime source for its extraction.
Interfering signal transduction pathway of tumor cells
In the signal transduction of tyrosine phosphate receptor pathway, apigenin can inhibit the phosphorylation of ECFR receptor itself and inhibit its effect factor MAPK tyrosine phosphorylation, thus making the pathway in the hindrance state to inhibit the growth of tumor cells.
By inhibiting the activity of cyclin, cyclin dependent protein kinase, and cyclin dependent protein kinase inhibitor, apigenin can interfere with the normal operation of the tumor cell cycle. It shows that apigenin can inhibit the proliferation of breast cancer cells in the C2/M phase.
Apigenin can significantly inhibit the overexpression of macrophages caused by lipopolysaccharide, thus significantly reducing the intracellular NO content. In addition, cyclooxygenase plays a key role in the synthesis pathway of inflammatory factors. Apigenin can inhibit the expression of LPS induced by COX-2, thus reducing the formation of PC.
Apigenin can effectively remove lipid peroxides, free radical ions and superoxide anion through direct action or chelation, thus inhibiting the oxidative damage of these free radicals, such as DNA, low density lipoprotein and so on.
The role of the cardiovascular system
The relaxation effect of apigenin on the vasoconstriction induced by epinephrine was carried out in a concentration dependent manner, and the effect of apigenin on endothelium intact blood vessels was significantly greater than that of endothelium.
Anti atherosclerotic effect
An important cause of atherosclerosis and many vascular diseases is the abnormal proliferation of vascular smooth muscle cells. In a certain concentration range, apigenin can significantly inhibit the proliferation of vascular smooth muscle cells in a concentration dependent manner.
Health benefits of apigenin
Apigenin, when complemented with the potential and effectiveness of other flavonoids like luteolin acts as an excellent resistor against the synthesis of fatty acids that are the major cause of prostate cancer.
Apigenin has been proven as a counteracting agent to leukemia cells and induces a natural apoptosis within the cell growth patterns to suppress the progression of leukemia.
Apigenin prevents the progression and development of tumor cell growth by blocking the blood capillaries that serve as fuel for their activity inside the gastro intestinal tract.
It sensitizes and eliminates cancer cells through naturally induced apoptosis and controls the causes of gastro intestinal cancer that relate with the microenvironment. It decreases cell glucose uptake, regulates extracellular matrix and resists passages that spread metastatic activity around the region.
a significant decrease in the risk and potential of ovarian cancer was observed due to regular apigenin intake.
After a course of medical experiments, it has been inferred that apigenin, together with luteolin, works as a potent chemotherapeutic agent, acting on myelogenous erythroleukaemia parallel and bladder carcinoma; two active cancer cell lines.
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